Hey, I was just talking about this!
The weekend before last, at KantCon. For those who just started reading this blog (and welcome), The Ultimate Hero is this sci-fi/superhero RPG by Paragon Notion, and it basically has everything but the kitchen sink in a fun little package. I have been thinking that the game really needs an "Appendix N," a list of the inspirational material for the game designers so the player can have some idea of what sort of style they were shooting for.
If not for KantCon, my answer would be once again D&D 5th Ed, which I've been running three weekends a month since January.